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KMID : 0615720090260060091
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Jouranl of Korean Acupuncture and Moxibustion society
2009 Volume.26 No. 6 p.91 ~ p.100
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Analgesic Effect of Clematidis Radix (CR) Herbal- acupuncture on the Test Rats with Induced Acute Pain
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Choi Won-Joo
Kim Ki-Bong
Kim Kyung-Ho
Kim Jang-Hyun
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Abstract
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Objectives : The objective of this study is to investigate Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR) herbal-acupuncture on the test rats with induced acute pain.
Methods : The effects of Clematidis Radix (CR)-distillates were investigated in three types of models with three different pain. Highly purified distillate of CR called CR herbal-acupuncture was injected to Zusanli (ST36) acupoint. In the tail flick test, the CR herbal-acupuncture treatment did not show a significant effect of relieving acute pain. To investigate the anti-inflammatory effect of CR herbal-acupuncture, the second testing model’pain was induced by injecting formalin to its planter. For the last model, carrageenan was injected into tarsal joint. the medicinal effect of CR herbal-acupuncture was evaluated through the behavioral analyses such as licking time, weight distribution ratio and ankle circumference.
Results : In the formalin test, the analgesic effect of CR herbal-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It was proven by weight distribution ratio testing and ankle edema testing that herbal-acupuncture of CR inhibited arthritis caused by the carrageenan.
Conclusions : These results revealed that CR herbal-acupuncture was effective to alleviate the inflammatory pain and could be used as an analgesic treatment with an anti-inflammatory effect.
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KEYWORD
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Clematidis Radix, herbal-acupuncture, Jusanli(ST36), analgesia, arthritis
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